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Year Number of Results
1998 3
1999 2
2000 1
2001 5
2002 2
2003 1
2004 2
2005 1
2006 4
2007 10
2008 7
2009 4
2010 2
2011 1
2012 4
2013 3
2014 3
2015 3
2016 7
2017 6
2018 6
2019 11
2020 5
2021 11
2022 7
2023 13
2024 0

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110 results

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Page 1
SIRPα-CD47 Immune Checkpoint Blockade in Anticancer Therapy.
Veillette A, Chen J. Veillette A, et al. Trends Immunol. 2018 Mar;39(3):173-184. doi: 10.1016/j.it.2017.12.005. Epub 2018 Jan 11. Trends Immunol. 2018. PMID: 29336991 Review.
Research so far has largely focused on improving adaptive immune functions, but recent studies have indicated that the signal-regulatory protein (SIRP)alpha-CD47 pathway, a phagocytosis checkpoint in macrophages and other innate immune cells, may be an interesting t …
Research so far has largely focused on improving adaptive immune functions, but recent studies have indicated that the signal-regulatory pro …
SIRP Alpha Protein Downregulates in Human Astrocytoma: Presumptive Involvement of Hsa-miR-520d-5p and Hsa-miR-520d-3p.
Deshpande RP, Chandra Sekhar YBVK, Panigrahi M, Babu PP. Deshpande RP, et al. Mol Neurobiol. 2017 Dec;54(10):8162-8169. doi: 10.1007/s12035-016-0302-8. Epub 2016 Nov 29. Mol Neurobiol. 2017. PMID: 27900675
In the present study, we investigated the involvement of miR-520d-5p and miR-520d-3p in regulation of SIRP alpha expression. Here, we report mRNA and protein expression profile of SIRP alpha in 39 surgically resected human astrocytoma tissue sam …
In the present study, we investigated the involvement of miR-520d-5p and miR-520d-3p in regulation of SIRP alpha expression. H …
Soluble SIRP-Alpha Promotes Murine Acute Lung Injury Through Suppressing Macrophage Phagocytosis.
Shen Q, Zhao L, Pan L, Li D, Chen G, Chen Z, Jiang Z. Shen Q, et al. Front Immunol. 2022 May 12;13:865579. doi: 10.3389/fimmu.2022.865579. eCollection 2022. Front Immunol. 2022. PMID: 35634325 Free PMC article.
To define the role of soluble SIRP-alpha in the pathogenesis of ALI, we established murine ALI in wild-type (WT) and SIRP-alpha knock-out (KO) mice by intratracheal administration of LPS. ...Blockade of soluble SIRP-alpha activity in ALI …
To define the role of soluble SIRP-alpha in the pathogenesis of ALI, we established murine ALI in wild-type (WT) and SIRP …
SIRP-alpha-IL-6 axis induces immunosuppressive macrophages in non-small-cell lung cancer.
Wang B, Pan L, Chen M, Ma Y, Gao J, Tang D, Jiang Z. Wang B, et al. Biochem Biophys Res Commun. 2023 Nov 19;682:386-396. doi: 10.1016/j.bbrc.2023.10.035. Epub 2023 Oct 10. Biochem Biophys Res Commun. 2023. PMID: 37844448
Signal regulatory protein-alpha (SIRPalpha) and IL-6 participate in the induction of tumor immune suppressive environment and facilitate tumor growth. ...Further in vitro studies showed that blockade of SIRPalpha signaling by anti-SIRPalpha effectively improved phagocytosi …
Signal regulatory protein-alpha (SIRPalpha) and IL-6 participate in the induction of tumor immune suppressive environment and facilit …
Covalent conjugation of extracellular vesicles with peptides and nanobodies for targeted therapeutic delivery.
Pham TC, Jayasinghe MK, Pham TT, Yang Y, Wei L, Usman WM, Chen H, Pirisinu M, Gong J, Kim S, Peng B, Wang W, Chan C, Ma V, Nguyen NTH, Kappei D, Nguyen XH, Cho WC, Shi J, Le MTN. Pham TC, et al. J Extracell Vesicles. 2021 Feb;10(4):e12057. doi: 10.1002/jev2.12057. Epub 2021 Feb 16. J Extracell Vesicles. 2021. PMID: 33643546 Free PMC article.
The method is also applicable to the conjugation of EVs with peptides and nanobodies targeting other receptors, such as HER2 and SIRP alpha, and the conjugated EVs can deliver RNA in addition to small molecules, supporting the versatile application of EVs in cancer …
The method is also applicable to the conjugation of EVs with peptides and nanobodies targeting other receptors, such as HER2 and SIRP …
IFN-beta, IFN-gamma, and TNF-alpha decrease erythrophagocytosis by human monocytes independent of SIRP-alpha or SHP-1 expression.
de Almeida AC, Barbosa SM, de Lourdes Rios Barjas-Castro M, Olalla-Saad ST, Condino-Neto A. de Almeida AC, et al. Immunopharmacol Immunotoxicol. 2012 Dec;34(6):1054-9. doi: 10.3109/08923973.2012.697470. Epub 2012 Jun 28. Immunopharmacol Immunotoxicol. 2012. PMID: 22738830
OBJECTIVES: The aim of this work was to evaluate the effect of IFN-beta, IFN-gamma, and TNF-alpha on erythrophagocytosis and assess the effect on expression of SIRP-alpha and SHP-1 in human monocytes. ...Monocytes cultured with IFN-beta did not show an …
OBJECTIVES: The aim of this work was to evaluate the effect of IFN-beta, IFN-gamma, and TNF-alpha on erythrophagocytosis and assess t …
Pre-Clinical Development of a Humanized Anti-CD47 Antibody with Anti-Cancer Therapeutic Potential.
Liu J, Wang L, Zhao F, Tseng S, Narayanan C, Shura L, Willingham S, Howard M, Prohaska S, Volkmer J, Chao M, Weissman IL, Majeti R. Liu J, et al. PLoS One. 2015 Sep 21;10(9):e0137345. doi: 10.1371/journal.pone.0137345. eCollection 2015. PLoS One. 2015. PMID: 26390038 Free PMC article.
CD47 serves as the ligand for a receptor on these innate immune cells, SIRP-alpha, which in turn delivers an inhibitory signal for phagocytosis. ...The resulting humanized 5F9 antibody (Hu5F9-G4) bound monomeric human CD47 with an 8 nM affinity. Hu5F9-G4 indu …
CD47 serves as the ligand for a receptor on these innate immune cells, SIRP-alpha, which in turn delivers an inhibitory signal …
SLAMF7 is critical for phagocytosis of haematopoietic tumour cells via Mac-1 integrin.
Chen J, Zhong MC, Guo H, Davidson D, Mishel S, Lu Y, Rhee I, Pérez-Quintero LA, Zhang S, Cruz-Munoz ME, Wu N, Vinh DC, Sinha M, Calderon V, Lowell CA, Danska JS, Veillette A. Chen J, et al. Nature. 2017 Apr 27;544(7651):493-497. doi: 10.1038/nature22076. Epub 2017 Apr 19. Nature. 2017. PMID: 28424516 Free PMC article.
Phagocytosis by macrophages plays a critical role in cancer control. Therapeutic blockade of signal regulatory protein (SIRP)-alpha, an inhibitory receptor on macrophages, or of its ligand CD47 expressed on tumour cells, improves tumour cell elimination in vitro and …
Phagocytosis by macrophages plays a critical role in cancer control. Therapeutic blockade of signal regulatory protein (SIRP)-alph …
The interaction between signal regulatory protein alpha (SIRPalpha) and CD47: structure, function, and therapeutic target.
Barclay AN, Van den Berg TK. Barclay AN, et al. Annu Rev Immunol. 2014;32:25-50. doi: 10.1146/annurev-immunol-032713-120142. Epub 2013 Nov 6. Annu Rev Immunol. 2014. PMID: 24215318 Review.
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPalpha (also termed CD172a or SHPS-1). SIRPalpha is the prototypic member of the SIRP paired receptor family of closely related SIRP proteins. Engagement of SIR …
CD47 is a broadly expressed membrane protein that interacts with the myeloid inhibitory immunoreceptor SIRPalpha (also termed CD172a or SHPS …
Just eat it: A review of CD47 and SIRP-alpha antagonism.
Oronsky B, Carter C, Reid T, Brinkhaus F, Knox SJ. Oronsky B, et al. Semin Oncol. 2020 Apr-Jun;47(2-3):117-124. doi: 10.1053/j.seminoncol.2020.05.009. Epub 2020 May 30. Semin Oncol. 2020. PMID: 32517874 Review.
110 results